Rectal colonic mural hematoma following enema for constipation while on therapeutic anticoagulation Open Access

Abstract

INTRODUCTION

Older adults with abdominal pain have a six- to eight-fold increase in mortality compared to younger patients [1, 2]. Intramural colonic hematomas manifest rarely as complications following blunt traumas or accompanying diseases with bleeding tendency.

CASE REPORT

A 72-year-old male with cerebral palsy was admitted following development of symptomatic pulmonary embolism for the initiation of therapeutic anticoagulation including Heparin drip and oral Coumadin. Prior to initiation of therapeutic anticoagulation, he had a computed tomography (CT) scan angiogram of his chest, abdomen and pelvis. A pulmonary embolism and large stool burden were noted on the CT scan and tap water enemas were initiated following the start of the Heparin drip and Coumadin initiation (Fig. 1A–C). The following day the patient developed new onset abdominal pain and distention. A complete blood count demonstrated an acute drop in hemoglobin from 12 to 6, partial thromboplastin time 100 and international normalized ratio was 3.5. The patient was transfused 2 units packed red blood cells, but his hemoglobin did not increase. On exam there was also some new mucoid blood drainage and abdominal tenderness with distension. A repeat CT scan angiogram demonstrated a 15 × 6 × 3 cm abdominal intramural hematoma (Fig. 1D,E). Bedside proctoscopy revealed a dusky rectum with dark swollen mucosa at 20 cm. Given the increasing abdominal pain and concern for perforation as well as lack of response to blood products, an exploratory laparotomy was performed. At laparotomy a 30 × 15 cm abdominal recto-sigmoid hematoma was discovered distending the previously capacious bowel wall without perforation (Fig. 2). Large clamps were used to transect the distal bowel at the recto-sigmoid junction and the area of transection was oversewn. An end colostomy was created using normal sigmoid colon. Pathologic analysis revealed colonic wall ischemia and hemorrhage (Fig. 3). It is likely that dilated colon allowed for a large amount of hematoma to accumulate. The patient recovered post-operatively and was discharged following return of bowel function. Following the operation on postoperative Day 1 coagulation was resumed without any additional issues.

Figure 1:

CT – Abdomen and Pelvis with intravenous contrast. Admission imaging demonstrating large colonic stool burden in the axial (A), coronal (B) and sagittal orientation (C). CT abdomen and pelvis following enema demonstrating large colonic wall hematoma axial (D), coronal (E) and sagittal orientation (F).

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Figure 2:

Intraoperative photograph of the large intramural hematoma of the sigmoid colon descending into the recto-sigmoid junction.

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Figure 3:

Pathologic colonic cross section. (A) Hemorrhagic infarction of the sigmoid colon. (B) Ischemic bowel with pseudomembrane formation. (C) Ischemic bowel with hemorrhage and pseudomembrane formation.

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DISCUSSION

Intramural hematomas of the alimentary tract are uncommon, occurring most frequently in the setting of blunt abdominal trauma (duodenum most common, colon least common), and in 15–36% are spontaneous in patients with underlying hematologic disease or on anticoagulant therapy [3]. Large hematomas are usually found in the submucosal layer were microvascular structures reside [4].

Hemorrhagic complications while on therapeutic anticoagulation are well recognized. The incidence of all bleeding complications during anticoagulation therapy ranges from 5 of 48%, but gastrointestinal hemorrhage occurs in only 2 to 4% of patients [5]. Small bowel hematoma has an incidence of 1 case per 2500 anticoagulated patients per year, while large bowel hematomas have an even lower incidence in the literature [6]. Gastrointestinal complications following anticoagulation can present with bleeding into the intestinal lumen, usually related to some underlying mucosal abnormality [7], retroperitoneal hemorrhage or bleeding into intra-abdominal organs; less common are intramural hematomas.

Rectal hematoma and subsequent perforation have been described in patients following enemas and radiographic contrast enemas [8] due to both instrumentation and hydrostatic pressure [9]. One study demonstrated that the incidence of iatrogenic large bowel perforations ranges from 0.1 to 0.9% following colonoscopy and barium enemas. The differential diagnosis of abdominal pain for a patient on anticoagulation is broad including rectus sheath hematoma, retroperitoneal hematoma, intestinal/mesenteric hematoma, bleeding diverticula and rectal trauma from enema or foreign object.

The use of CT as the first imaging modality in the evaluation of patients with acute abdominal complaints especially in the elderly population [10]. CT characteristics of colonic hematoma include circumferential wall thickening, intramural hyper-density, luminal narrowing and intestinal obstruction. Additional adjuncts for diagnosis consist of rigid proctoscopy which demonstrate colonic intramural hematomas as round shaped, dark reddish submucosal masses often obstructing the luminal space.

For patients with intramural hematomas treatment decisions depend on the symptoms and clinical findings. Conservative management includes removing the anticoagulation therapy, correcting coagulopathy, intestinal decompression and avoiding oral intake while awaiting spontaneous resorption of the hematoma [11]. However only 30% of colonic hematomas respond to conservative management. The challenge is to distinguish patients with self-limiting intramural hematoma from those with more severe pathology. Conventional physical exam signs are inadequate to distinguish more ill patients as even a simple hematoma may also present with high fevers, leukocytosis and rebound tenderness.

If the intramural hematoma causes obstruction or if the cause of the bowel obstruction is unknown, surgical intervention for colonic hematoma is warranted. Drainage of the hematoma may increase the risk of serious infection as it introduces bacteria to a previously sterile hematoma.

A review of the literature demonstrates a shift in the management of colonic hematomas over the past 50 years. Cases prior to 1969 were most commonly treated with surgical intervention [12]. However, following 2010 they were managed more frequently conservatively [13].

Treatment of colonic hematomas depends on symptoms and clinical findings [11, 14]. Overall bowel obstruction in a patient on anticoagulation with acute abdominal pain results in operative exploration in 67% (42 of 51 patients). For those reasons we recommend laparotomy for those who fail to improve 24–36 hours [15]. Indications for immediate surgical intervention include active and persistent intra-abdominal bleeding, intestinal wall ischemia with or without bowel perforation and peritonitis [16]. Surgical treatment consists of bowel resection with primary anastomosis with or without diverting colostomy. Many case series and reports have demonstrated that patients with distal colonic hematomas required diverting colostomies 80% of the time [17].

Procedural alternatives to surgical intervention have been described in case reports and series. Endoscopic drainage requires colonic wall viability [18] but could result in relief of the ‘tamponade effect’ of the hematoma [19]. Selective mesenteric embolization can be performed in patients with an active blush into the colonic wall with an 85% success rate, and an overall 20% of complication as a result of the procedure.

Recto-sigmoid hematomas should be considered as a diagnosis for a patient with a dropping hemoglobin and abdominal pain in the setting of an enema on therapeutic anticoagulation. Characteristic clinical and imaging findings may aid in making a timely diagnosis. There is an increasing role for conservative management. If obvious signs of clinical deterioration such as free air and failure to respond to correction of coagulation are identified, then operative intervention should commence.

ACKNOWLEDGEMENTS

We would like to thank Department of Surgery (Nicholas Meyer, M.D.) for operative assistance, the Department of Radiology (Robert Lyons, M.D.) imaging interpretation and the Department of Pathology (Joseph A. Novak, M.D.) for the histologic slides at Columbia St. Mary's Hospital in Milwaukee, WI.

CONFLICT OF INTEREST STATEMENT

The authors declare that there is no conflict of interests regarding the publication of this paper.

REFERENCES